期刊
HUMAN BRAIN MAPPING
卷 40, 期 18, 页码 5354-5369出版社
WILEY
DOI: 10.1002/hbm.24777
关键词
autism; functional connectivity; functional magnetic resonance imaging; resting-state; semi-metricity
资金
- Autism Research Trust
- China Scholarship Council [201706070063]
- European Union's Seventh Framework Programme [FP7/2007-2013]
- Fundamental Research Funds for the Central Universities [2672018ZYGX2018J079, ZYGX2016J187]
- Innovative Medicines Initiative Joint Undertaking [115300]
- Medical Research Council
- National Institute for Health Research Cambridge Biomedical Research Centre
- National Natural Science Foundation of China [61533006, 61673089, 81771919, 81871432]
- O'Brien Scholars Program in the Child and Youth Mental Health Collaborative
- Sichuan Science and Technology Program [2018TJPT0016]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20120185110028]
- British Academy
- Wellcome Trust
- ERC [755816]
- Slaight Family Child and Youth Mental Health Innovation Fund
- UK Medical Research Council [GO 400061]
- Centre for Addiction and Mental Health (CAMH) Foundation
- Ontario Brain Institute
- Jesus College Cambridge
- European Autism Interventions - a Multicentre Study for Developing New Medications (EU-AIMS)
- European Research Council (ERC) [755816] Funding Source: European Research Council (ERC)
Autism is a neurodevelopmental condition characterized by atypical brain functional organization. Here we investigated the intrinsic indirect (semi-metric) connectivity of the functional connectome associated with autism. Resting-state functional magnetic resonance imaging scans were acquired from 65 neurotypical adults (33 males/32 females) and 61 autistic adults (30 males/31 females). From functional connectivity networks, semi-metric percentages (SMPs) were calculated to assess the proportion of indirect shortest functional pathways at global, hemisphere, network, and node levels. Group comparisons were then conducted to ascertain differences between autism and neurotypical control groups. Finally, the strength and length of edges were examined to explore the patterns of semi-metric connections associated with autism. Compared with neurotypical controls, autistic adults displayed significantly higher SMP at all spatial scales, similar to prior observations in adolescents. Differences were primarily in weaker, longer-distance edges in the majority between networks. However, no significant diagnosis-by-sex interaction effects were observed on global SMP. These findings suggest increased indirect functional connectivity in the autistic brain is persistent from adolescence to adulthood and is indicative of reduced functional network integration.
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