期刊
GENOMICS
卷 112, 期 2, 页码 1477-1480出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2019.08.018
关键词
Copy number variation; Association; Body size; African goats
资金
- AFRI from the USDA National Institute of Food and Agriculture (NIFA) Animal Tools and Resources -Animal Breeding, Genetics and Genomics Program [2018-06524]
- BARD from the US-Israel Binational Agricultural Research and Development (BARD) Fund [US-4997-17]
Using the CaprineSNP50 data generated by the AGIN consortium, we detected common CNVs in 126 samples from four African indigenous goat breeds. A total of 30 CNVs ranging from 30,237 bp to 4,910,757 bp were identified. These CNVs were then associated with six growth traits by a linear regression analysis. Three significant associations were identified between two CNVs and two body traits after false discovery rate (FDR) correction (P < .05). One of them (CNV27) was significantly associated with both chest width and width of pin bones. It overlaps the SNX29 gene, the Gene Ontology (GO) annotations of which indicate CNV27 could be a potential functional candidate for meat production, health and reproduction traits. To our knowledge, this study is the first CNV-based association test of growth traits using SNP chip data in African meat goats.
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