期刊
GENES & DEVELOPMENT
卷 33, 期 17-18, 页码 1098-1116出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.327312.119
关键词
gene regulation; genomics; KRAB zinc finger; fetrotransposons; transposable elements; piRNA
资金
- National Institutes of Health [R35GM122550, U01HG009391, R01GM112972]
Transposable elements (TEs) are mobile DNA sequences that colonize genomes and threaten genome integrity. As a result, several mechanisms appear to have emerged during eukaryotic evolution to suppress TE activity. However, TEs are ubiquitous and account for a prominent fraction of most eukaryotic genomes. We argue that the evolutionary success of TEs cannot be explained solely by evasion from host control mechanisms. Rather, some TEs have evolved commensal and even mutualistic strategies that mitigate the cost of their propagation. These co-evolutionary processes promote the emergence of complex cellular activities, which in turn pave the way for cooption of TE sequences for organismal function.
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