期刊
GENES & DEVELOPMENT
卷 33, 期 17-18, 页码 1136-1158出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.328633.119
关键词
circadian; diabetes; hypothalamus; obesity
资金
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01DK090625, R01DK113011, R01DK100814]
- National Institute on Aging [P01AG011412]
- Chicago Biomedical Consortium [S-007]
- University of Chicago Diabetes Research and Training Center [P60DK020595]
- Swedish Society for Medical Research
- Swedish Brain Research Foundation
- [T32 GM008061]
Circadian rhythms are driven by a transcription-translation feedback loop that separates anabolic and catabolic processes across the Earth's 24-h light-dark cycle. Central pacemaker neurons that perceive light entrain a distributed clock network and are closely juxtaposed with hypothalamic neurons involved in regulation of sleep/wake and fast/feeding states. Gaps remain in identifying how pacemaker and extrapacemaker neurons communicate with energy-sensing neurons and the distinct role of circuit interactions versus transcriptionally driven cell-autonomous clocks in the timing of organismal bioenergetics. In this review, we discuss the reciprocal relationship through which the central clock drives appetitive behavior and metabolic homeostasis and the pathways through which nutrient state and sleep/wake behavior affect central clock function.
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