期刊
GASTROENTEROLOGY
卷 158, 期 2, 页码 368-388出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2019.06.047
关键词
Colorectal Cancer; Adenoma; Chemoprevention
资金
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases [K08DK106489]
- Lustgarten Family Colon Cancer Research Fund
- American Cancer Society [MRSG-13-144-01-CPHPS]
Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from CRC, chemoprevention strategies have the potential to further reduce CRC incidence and mortality. Chemoprevention agents might be used for average-risk as well as high-risk groups, and to prevent CRC recurrence after therapy. CRC chemoprevention agents that have been studied include aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, statins, agents that target metabolic pathways, and vitamins and minerals. We review the prospect of chemoprevention of CRC, results from preclinical and human studies, challenges, and future directions.
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