期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 12, 页码 2469-2472出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.04.085
关键词
Blaps japanensis; Insects; N-Acetyldopamine dimers; COX-1; COX-2
资金
- National Natural Science Foundation of China [21172223]
- Research Fund of 'South Drug' Research Collaborative Innovation Organization
Blapsols A-D (1-4), four new compounds possessing a 2,3-dihydrobenzo[b][1,4]dioxin group, together with five known N-acetyldopamine dimers (5-9), were isolated from Blaps japanensis. Their structures including the absolute configuration of (+)-1 were determined by means of spectroscopic and X-ray crystallographic methods. Chiral HPLC was used to separate (-)- and (+)-enantiomers of compounds 1-4, which were isolated from this insect as racemic mixtures. All the compounds were found to have inhibitory effects towards COX-2 with IC50 values in the range of 1.3-17.8 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
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