期刊
FUNGAL GENETICS AND BIOLOGY
卷 130, 期 -, 页码 19-30出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.fgb.2019.04.014
关键词
Ganoderma lucidum; Cystathionine beta-synthase; Hydrogen sulfide; Ganoderic acids; Calcium
资金
- National Natural Science Foundation of China [81773839, 31672212]
- Natural Science Foundation of Jiangsu Province [BK20171377]
- Earmarked Fund for China Agriculture Research System [CARS-20]
Hydrogen sulfide (H2S), an emerging small-molecule signalling agent, was recently shown to play a significant role in many physiological processes, but relatively few studies have been conducted on microorganisms compared with mammals and plants. By studying the pretreatment of H2S donor sodium hydrosulfide (NaHS) and the scavenger hypotaurine (HT) and Cystathionine beta-synthase silenced strains, we found that H2S could alleviate the H2S-induced ganoderic acids (GAs) biosynthesis. Our transcriptome results also showed that many signaling pathways and metabolic pathways, such as the glycolysis, TCA, oxidative phosphorylation and pentose phosphate pathway, are influenced by H2S. Further experimental results indicated that H2S could affect the physiological process of Ganoderma lucidum by interacting with multiple signals, including ROS, NO, AMPK, sphingolipid, mTOR, phospholipase D and MAPK, and physiological and pharmacological analyses showed that H2S might alleviate the biosynthesis of GAs by inhibiting the intracellular calcium in G. lucidum.
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