期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 25, 期 13, 页码 2686-2689出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.04.083
关键词
Hybrid liposomes; Rheumatoid arthritis; Collagen-induced arthritis mouse models; Chemotherapy; In vivo
资金
- Ministry of Education, Science, and Culture of Japan [25289299, 25420843, 15k12527]
- Grants-in-Aid for Scientific Research [25420843, 15K12527] Funding Source: KAKEN
Therapeutic effects of HL for a collagen-induced arthritis (CIA) mouse models of HL-23 composed of 95 mol % L-alpha-dimyristoylphosphatidylcholine (DMPC) and 5 mol % polyoxyethylenedodecylether (C-12(EO)(23)) in vivo were examined. Remarkably high therapeutic effects of HL-23 for CIA mouse models were obtained on the basis of clinical assessment of arthritis. The reduction of hyperplastic synovial membrane (pannus tissue) and destruction of the cartilage and bone by HL-23 was revealed on the basis of hematoxylin and eosin (HE) and safranin O staining. Furthermore, the downregulation of inflammatory cytokines such as interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and IL-6 for CIA mouse models treated with HL-23 were investigated. Remarkably high therapeutic effects without joint swelling were obtained in CIA mouse models treated with HL-23. (C) 2015 The Authors. Published by Elsevier Ltd.
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