期刊
FOOD HYDROCOLLOIDS
卷 93, 期 -, 页码 261-269出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2019.02.039
关键词
Resveratrol; Zein nanoparticles; Bioaccessibility; Antioxidant capacity; Delivery systems
资金
- National Natural Science Foundation of China [31771920]
- International Cooperation Research Program of Guangdong Provincial Department of Science and Technology [2015A050502051]
- National Institute of Food and Agriculture, USDA, Massachusetts Agricultural Experiment Station [MAS00491]
- USDA, AFRI [2013-03795, 2014-67021, 2016-25147, 2016-08782]
Zein-pectin core/shell nanoparticles loaded with resveratrol were fabricated using a combination of the anti-solvent precipitation and electrostatic deposition methods. These nanoparticles were stable to aggregation from pH 2 to 7 and had good heat stability (80 degrees C for 1 h). The nanoparticles were exposed to a simulated gastrointestinal tract (GIT) containing stomach and small intestine phases, and their bioaccessibility and antioxidant capacity were then measured. The bioaccessibility of the encapsulated resveratrol was higher than that of free resveratrol. Moreover, the in vitro antioxidant capacity of resveratrol was greatly enhanced when it was encapsulated inside the biopolymer nanoparticles, as shown by more potent ABTS(+). radical scavenging and ferric ion reducing power. The gastrointestinal fluids collected after digestion of the encapsulated resveratrol also exhibited strong intracellular reactive oxygen species scavenging activity. Our results suggest that the biopolymer nanoparticles produced in this study may be an effective oral delivery system for resveratrol that could be used in functional foods or nutraceutical supplements.
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