期刊
FITOTERAPIA
卷 138, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2019.104357
关键词
Salinispora arenicola; Marine actinomycete; 4-Hydroxy-pyran-2-one; 3-Hydroxy-N-methyl-2-oxindole; X-ray structure analysis; Antimicrobial activity
资金
- CNPq [420454/2016-0, 309060/2016-8]
- CAPES/FUNCAP [88887.113263/2015-01]
- INCT BioNat [465637/2014-0]
Three new 3-hydroxy-N-methyl-2-oxindole (1 and 2) and 4-hydroxy-pyran-2-one (3) derivatives, along with the known 3-hydroxy-N-methyl-2-oxindole (4) and 6-methoxy-N-methylisatin (5) were isolated from a marine Salinispora arenicola strain from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the new compounds were elucidated by a combination of spectroscopic (1D and 2D NMR and HR-ESIMS) data, including single-crystal X-ray diffraction analysis for 2 and 3. Compounds 1 to 5 were assayed for their antimicrobial properties, but only 4 and 5 were active against Enterococcus faecalis with MIC value of 15.6 mu g/mL.
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