Deep perifoveal vessel density as an indicator of capillary loss in high myopia

Objectives This study investigates the macular vasculature of both vascular layers in different degrees of myopia by optical coherence tomography angiography (OCTA). Methods One hundred and forty-five eyes of 145 healthy subjects with spherical equivalents (SE) ranging from +0.50 to -16.50 dioptres were divided into three groups. The foveal avascular zone (FAZ) area and vessel density (VD) of OCTA images were compared. Results Compared with other groups, high myopia had a larger FAZ and less perifoveal VD in both layers and less deep total VD. Compared with other myopia, high myopia had less total VD in the superficial layer and parafoveal VD in the deep layer. Between emmetropia and low myopia, there was a difference only in the deep parafoveal VD. Except for the parafoveal VD in both layers and the superficial total VD, there were significant correlations of the FAZ with axial length (AL) and SE as well as VD. The deep perifoveal VD was most associated with high myopia. Conclusions An increased FAZ and decreased VD in both layers were correlated with AL elongation. The decreasing deep perifoveal VD was most associated with high myopia. OCTA may provide additional information regarding the progression of pathologies in high myopia.