期刊
EUROPEAN RADIOLOGY
卷 30, 期 3, 页码 1419-1425出版社
SPRINGER
DOI: 10.1007/s00330-019-06362-x
关键词
Mammography; Phase contrast; Interferometry
资金
- FP7 Ideas: European Research Council [2012-StG 310005-PhaseX] Funding Source: Medline
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung [CRS112-154472 MedXPhase] Funding Source: Medline
Objectives Grating-interferometry-based mammography (GIM) might facilitate breast cancer detection, as several research works have demonstrated in a pre-clinical setting, since it is able to provide attenuation, differential phase contrast, and scattering images simultaneously. In order to translate this technique to the clinics, it has to be adapted to cover a large field-of-view within a clinically acceptable exposure time and radiation dose. Methods We set up a grating interferometer that fits into a standard mammography system and fulfilled the aforementioned conditions. Here, we present the first mastectomy images acquired with this experimental device. Results and conclusion Our system performs at a mean glandular dose of 1.6 mGy for a 5-cm-thick, 18%-dense breast, and a field-of-view of 26 x 21 cm2. It seems to be well-suited as basis for a clinical-environment device. Further, dark-field signals seem to support an improved lesion visualization. Evidently, the effective impact of such indications must be evaluated and quantified within the context of a proper reader study.
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