期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 137, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejps.2019.104967
关键词
Poorly water-soluble drugs; Formulation; Bioavailability; Drug delivery; Lipid formulations; Solid state
资金
- COST (European Cooperation in Science and Technology) [CA16205]
Poorly water-soluble drugs continue to be a problematic, yet important class of pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in discovery is still high, and their development is usually limited by our lack of a complete understanding of how the complex chemical, physiological and biochemical processes that occur between administration and absorption individually and together impact on bioavailability. This review defines the challenge presented by these drugs, outlines contemporary strategies to solve this challenge, and consequent in silico and in vitro evaluation of the delivery technologies for poorly water-soluble drugs. The next steps and unmet needs are proposed to present a roadmap for future studies for the field to consider enabling progress in delivery of poorly water-soluble compounds.
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