期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2019, 期 37, 页码 6359-6368出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201901140
关键词
Carbamates; Unsymmetrical ureas; Heterogeneous catalysis; Carbonylation; Domino reactions; Curtius rearrangement
资金
- research council of Shiraz University
A palladium-catalyzed domino method for the direct synthesis of carbamates and ureas has been developed by using readily available and economical starting materials (aryl halide, carbon monoxide, sodium azide, amines and alcohols) in a one-pot approach. The domino process underwent carbonylation, Curtius rearrangement, and nucleophilic addition. This protocol provides a step-economical and highly efficient reaction to access the wide range of valuable carbamates, symmetrical and unsymmetrical ureas with high yields under remarkable mild reaction conditions that are important factors in pharmaceutical science, biochemistry and agricultural industries. Furthermore, the magnetically recoverable nanocatalyst (Fe3O4@SiO2/Pd(II)) can be conveniently and swiftly recycled using external magnet and reused at least for seven times without noticeable loss of its catalytic activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据