期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 178, 期 -, 页码 606-622出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.06.008
关键词
Antivirals; Drug design/discovery; Common cold; Pleconaril; Rhinovirus; Enterovirus
资金
- NIH/NINDS [1R01NS102164-01]
- RFBR [17-54-30007]
The hydrophobic pocket within viral capsid protein 1 is a target to combat the rhino- and enteroviruses (RV and EV) using small molecules. The highly conserved amino acids lining this pocket enable the development of antivirals with broad-spectrum of activity against numerous RVs and EVs. Inhibitor binding blocks: the attachment of the virion to the host cell membrane, viral uncoating, and/or production of infectious virus particles. Syntheses and biological studies of the most well-known antipicornaviral capsid binders have been reviewed and we propose next steps in this research. (C) 2019 Published by Elsevier Masson SAS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据