Structure-activity relationship and synthetic methodologies of α-santonin derivatives with diverse bioactivities: A mini-review

alpha-Santonin, a sesquiterpene lactone isolated from Artemisia Santonica, possesses diverse bioactivities including antioxidant, anti-inflammation, immunosuppressive, anti-roundworm, anti-malaria, etc. However, its bioactivities are not satisfactory and need to be further optimized. Thus, many alpha-santonin derivatives were synthesized on the basis of rings A, B and C for the discovery of new analogues with prominent bioactivities. Herein, we reviewed and discussed the related synthetic methodologies, diverse bioactivities and structure-activity relationships (SAR) of alpha-santonin derivatives. (C) 2019 Elsevier Masson SAS. All rights reserved.