期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 176, 期 -, 页码 343-377出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.04.025
关键词
alpha-Glucosidase inhibitors; Heterocyclic compounds; Structure activity relationship (SAR); Docking study
资金
- Babasaheb Bhimrao Ambedkar University, Lucknow
- University Grants Commission
- Department of Science and Technology (DST), New Delhi, India [IFA-13, CH-110]
alpha-Glucosidase enzyme inhibition is an effective therapeutic decorum in the treatment of type 2 diabetes mellitus. Since 1990, three alpha-glucosidase inhibitors are known to exist clinically, Acarbose, Voglibose and Miglitol. Side effects and long synthetic routes to access them forced the researchers to move their focus to discover simple and small heterocyclic motifs that work as promising alpha-glucosidase inhibitors and may eventually lead to the management of postprandial hyperglycemic condition in T2DM. In this regards, this review deals with recently discovered heterocyclic molecules that have been evaluated to exhibit inhibition of alpha-glucosidase enzyme. (C) 2019 Elsevier Masson SAS. All rights reserved.
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