期刊
EMBO MOLECULAR MEDICINE
卷 11, 期 10, 页码 -出版社
WILEY
DOI: 10.15252/emmm.201910473
关键词
dyslipidemia; FGF21; photoreceptor; retinal metabolism; beta-oxidation
资金
- NIH [1R24EY024868, EY017017-13S1, R01EY030140, EY022938, R24 EY024864]
- BCH IDDRC [1U54HD090255]
- Swedish Research Council (DNR) [2016-01131]
- ALF [ALFGBG-717971]
- Wallenberg Foundations
- Blind Children's Center
- Deutsche Forschungsgemeinschaft [CA 1940/1-1]
- Beijing Municipal Natural Science Foundation [7192039]
- Boston Children's Hospital OFD/BTREC/CTREC Faculty Career Development Grant
- BrightFocus Foundation [NIH/R01EY029238]
- Manpei Suzuki Diabetes Foundation
- Intramural Research Program at the National Institute on Alcohol Abuse and Alcoholism
- Department of Veterans Affairs [BX003604]
- Manton Center for Orphan Disease Research
The light-sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled by photoreceptor energy demands. It is critical to understand the energy demands of photoreceptors and fuel sources supplying them to understand neurovascular diseases. Retinas are very rich in lipids, which are continuously recycled as lipid-rich photoreceptor outer segments are shed and reformed and dietary intake of lipids modulates retinal lipid composition. Lipids (as well as glucose) are fuel substrates for photoreceptor mitochondria. Dyslipidemia contributes to the development and progression of retinal dysfunction in many eye diseases. Here, we review photoreceptor energy demands with a focus on lipid metabolism in retinal neurovascular disorders.
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