期刊
DNA AND CELL BIOLOGY
卷 38, 期 9, 页码 1013-1021出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2019.4717
关键词
non-small-cell lung cancer (NSCLC); LEF1-AS1; EMT; lncRNA; miR-489
资金
- Quanzhou Science and Technology Plan Project [2018Z101]
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) could participate in diverse cancers. Among these, lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1) was recently identified as an oncogenic lncRNA, but little is known about its function in non-small-cell lung cancer (NSCLC). In the present study, we found that LEF1-AS1 was markedly upregulated in lung cancer tissues and could promote NSCLC cell proliferation and migration in vivo and in vitro. LEF1-AS1 could bind with miR-489 and further negatively regulate miR-489 to promote SRY-related HMG box transcription factor 4 (SOX4) expression. In conclusion, these data suggested that LEF1-AS1 promoted NSCLC tumorigenesis dependent on the miR-489-SOX4 axis and implicated the potential application of LEF1-AS1 for the prognosis and treatment of NSCLC.
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