期刊
DIABETOLOGIA
卷 62, 期 11, 页码 1961-1968出版社
SPRINGER
DOI: 10.1007/s00125-019-4969-z
关键词
Blood vessels; Diabetes; Endothelial cells; Pancreatic beta cells; Review; VEGF-A
资金
- Research Foundation Flanders (FWO)
- VUB Research Council
- Stichting Diabetes Onderzoek Nederland
- European Union
- Wetenschappelijk FondsWilly Gepts (WFWG) of the UZ Brussel
- European Foundation for the Study of Diabetes
- Agence Nationale de la Recherche (Laboratoire d'Excellence Revive, Investissement d'Avenir) [ANR-10-LABX-73]
Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult pancreas, islets depend on their dense capillary network to adequately respond to changes in plasma glucose levels. Vascular changes contribute to the onset and progression of both type 1 and type 2 diabetes. Impaired revascularisation of islets transplanted in individuals with type 1 diabetes is linked to islet graft failure and graft loss. This review summarises our understanding of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell development, physiology and disease. In addition, the therapeutic potential of modulating VEGF-A levels in beta and beta-like cells for transplantation is discussed.
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