期刊
DEVELOPMENTAL CELL
卷 50, 期 5, 页码 557-+出版社
CELL PRESS
DOI: 10.1016/j.devcel.2019.07.021
关键词
-
资金
- Welch Foundation [I-1873]
- Searle Foundation [SSP-2016-1482]
- NIH NIGMS [GM119768]
- AFAR [A15198]
- UT Southwestern Endowed Scholars Program
- Australian National Health and Medical Research Council (NHMRC) Senior research fellowship [APP1136021]
- NIH [2 PO1 HL20948-33]
Adipocytes store nutrients as lipid droplets (LDs), but how they organize their LD stores to balance lipid uptake, storage, and mobilization remains poorly understood. Here, using Drosophila fat body (FB) adipocytes, we characterize spatially distinct LD populations that are maintained by different lipid pools. We identify peripheral LDs (pLDs) that make close contact with the plasma membrane (PM) and are maintained by lipophorin-dependent lipid trafficking. pLDs are distinct from larger cytoplasmic medial LDs (mLDs), which are maintained by FASN1-dependent de novo lipogenesis. We find that sorting nexin CG1514 or Snazarus (Snz) associates with pLDs and regulates LD homeostasis at ER-PM contact sites. Loss of SNZ perturbs pLD organization, whereas Snz over-expression drives LD expansion, triacylglyceride production, starvation resistance, and lifespan extension through a DESAT1-dependent pathway. We propose that Drosophila adipocytes maintain spatially distinct LD populations and identify Snz as a regulator of LD organization and inter-organelle crosstalk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据