期刊
DEVELOPMENT
卷 146, 期 17, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.177188
关键词
Inner ear; Hair cells; Organoids; Regeneration; Stem cells
资金
- National Institutes of Health [DC14089]
- European Union Seventh Framework Programme [603029]
The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo. Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.
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