期刊
DEVELOPMENT
卷 146, 期 16, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.174706
关键词
Cell cycle; Embryogenesis; Epigenetic modification of chromatin; MEIS; PBX; Post-transcriptional and posttranslational control; Solid cancer
资金
- European Cooperation in Science and Technology [BM0805]
- Deutsche Forschungsgemeinschaft (DFG) [SCHU1218/3-3]
MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer summarizes recent findings about MEIS protein activity and regulation in development, and discusses new insights into the role of MEIS genes in disease, focusing on the pathogenesis of solid cancers.
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