期刊
CYTOTHERAPY
卷 21, 期 10, 页码 1019-1024出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2019.08.002
关键词
differentiation; immunomodulation; mesenchymal stromal cells; nomenclature; paracrine secretion; self-renewal; stem cells
The International Society for Cell & Gene Therapy (ISCT (R)) Mesenchymal Stromal Cell (ISCT MSC) committee offers a position statement to clarify the nomenclature of mesenchymal stromal cells (MSCs). The ISCT MSC committee continues to support the use of the acronym MSCs but recommends this be (i) supplemented by tissue-source origin of the cells, which would highlight tissue-specific properties; (ii) intended as MSCs unless rigorous evidence for stemness exists that can be supported by both in vitro and in vivo data; and (iii) associated with robust matrix of functional assays to demonstrate MSC properties, which are not generically defined but informed by the intended therapeutic mode of actions.
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