期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 57, 期 -, 页码 9-15出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2019.06.002
关键词
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资金
- National Institutes of Health
- Morris Scientific Discovery Award
- Academia Sinica
- Ministry of Science and Technology, Taiwan [MOST 107-2321-B-001-017]
Oxygen is essential to contemporary life, providing the major electron sink underlying cellular energy metabolism. In addition to providing energy, largely involving redox reactions within mitochondria, oxidative metabolism produces reactive byproducts that are damaging to cellular components. Eukaryotic organisms have evolved multiple physiological mechanisms and signaling pathways to deal with fluctuating levels of oxygen and reactive oxygen species (ROS), and many of these are used in animals to regulate developmental processes. Here we review recent findings showing how mitochondria, ROS and hypoxia signaling contribute to the regulation of early axial patterning in embryos, to nervous system development, and to the regulation of cell proliferation and differentiation during development and regeneration.
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