期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 51, 期 -, 页码 66-73出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2019.05.003
关键词
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资金
- Living Systems Institute
- EPSRC/UKRI
- UKRI [EP/R031428/1]
- EPSRC [EP/T002875/1, EP/R031428/1] Funding Source: UKRI
Monitoring the conformational dynamics of proteins is crucial for a better understanding of their biological functions. To observe the structural dynamics of proteins, it is often necessary to study each molecule individually. To this end, single-molecule techniques have been developed such as Forster resonance energy transfer and optical tweezers. However, although powerful, these techniques do have their limitations, for example, limited temporal resolution, or necessity for fluorescent labelling, and they can often only access a limited set of all protein motions. Here, within the context of established structural biology techniques, we review a new class of highly sensitive optical devices based on WGM, which characterise protein dynamics on previously inaccessible timescales, visualise motions throughout a protein, and track movements of single atoms.
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