期刊
CURRENT MEDICINAL CHEMISTRY
卷 27, 期 3, 页码 362-379出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190827153532
关键词
Polyoxometalates; antiviral; antibacterial; antitumor; normoglycemic activities; biomedicine
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [172023]
- bilateral project Serbia - Germany (DAAD-PPP) [451-03-01038/2015-09/16]
- CMST COST Action [CM1203]
- German Research Council (DFG) [KO-2288/20-1, KO-2288/16-1]
- Jacobs University
Background: Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., W-VI, Mo-VI, V-V). POMs are of interest in the fields of catalysis, electronics, magnetic materials and nanotechnology. Moreover, POMs were shown to exhibit biological activities in vitro and in vivo, such as antitumor, antimicrobial, and antidiabetic. Methods: The literature search for this peer-reviewed article was performed using PubMed and Scopus databases with the help of appropriate keywords. Results: This review gives a comprehensive overview of recent studies regarding biological activities of polyoxometalates, and their biomedical applications as promising anti-viral, anti-bacterial, anti-tumor, and anti-diabetic agents. Additionally, their putative mechanisms of action and molecular targets are particularly considered. Conclusion: Although a wide range of biological activities of Polyoxometalates (POMs) has been reported, they are to the best of our knowledge not close to a clinical trial or a final application in the treatment of diabetes or infectious and malignant diseases. Accordingly, further studies should be directed towards determining the mechanism of POM biological actions, which would enable fine-tuning at the molecular level, and consequently efficient action towards biological targets and as low toxicity as possible. Furthermore, biomedical studies should be performed on solution-stable POMs employing physiological conditions and concentrations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据