期刊
CURRENT MEDICINAL CHEMISTRY
卷 27, 期 39, 页码 6628-6642出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867326666190816230121
关键词
Parthenolide; triple negative breast cancer; sesquiterpene lactones; nuclear factor-kappa B; heterogeneity; natural products
资金
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Triple Negative Breast Cancers (TNBC) are heterogeneous and aggressive pathologies, with distinct morphological and clinical characteristics associated with their genetic diversity, epigenetics, transcriptional changes and aberrant molecular patterns. Treatment with anti-neoplastic drugs exerts systemic effects with low specificity, and incipient improvement in overall survival due to chemoresistance and recurrence. New alternatives for TNBC treatment are urgent and parthenolide or its analogues have been explored. Parthenolide is a sesquiterpene lactone with promising antitumor effects against TNBC cell lines. This review highlights the importance of parthenolide and its analogue drugs in TNBC treatment.
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