期刊
CURRENT ALZHEIMER RESEARCH
卷 16, 期 9, 页码 834-835出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567205016666190827120108
关键词
Alzheimer; 2,3-diphosphoglycerate; erythrocytes; erythropoietin; beta-amyloid; cognitive impairment
资金
- Hultmans stiftelse for forskning och bistand
- Konung Gustaf V och Drottning Victorias stiftelse
- Hjarnfonden
- Margaretha af Ugglas Stiftelse
- Stiftelsen for Gamla Tjanarinnor
- Gun and Bertil Stohne's stiftelse
Background: Alzheimer's Disease (AD) features the accumulation of beta-amyloid in erythrocytes. The subsequent red cell damage may well affect their oxygen-carrying capabilities. 2,3-diphosphoglycerate (2,3-DPG) binds to the hemoglobin thereby promoting oxygen release. It is theorized that 2,3-DPG is reduced in AD and that the resulting hypoxia triggers erythropoietin (EPO) release. Methods & Objective: To explore this theory, we analyzed red cell 2,3-DPG content and EPO in AD, mild cognitive impairment, and the control group, subjective cognitive impairment. Results: We studied (i) 2,3-DPG in red cells, and (ii) circulating EPO in AD, and both markers were unaffected by dementia. Disturbances of these oxygen-regulatory pathways do not appear to participate in brain hypoxia in AD.
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