期刊
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
卷 29, 期 11, 页码 1646-1652出版社
ASIAN-AUSTRALASIAN ASSOC ANIMAL PRODUCTION SOC
DOI: 10.5713/ajas.15.0660
关键词
Bovine Mammary Epithelial Cells [BMECs]; Mammalian Target of Rapamycin Complex 1 [mTORC1]; Elongation of Very-long-chain Fatty Acids 1 [ELOVL1]; DHA
资金
- Natural Sciences Foundation of China [31360561]
- Natural Science Foundation of Inner Mongolia Autonomous Region of china [2016MS0303, 2016BS0304]
- research program of innovation team from Inner Mongolia [NMGIRT-A1601]
Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth and metabolism and is sufficient to induce specific metabolic processes, including de novo lipid biosynthesis. Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene and the product of which was thought to be associated with elongation of carbon (C) chain in fatty acids. In the present study, we examined the effects of rapamycin, a specific inhibitor of mTORC1, on ELOVL1 expression and docosahexaenoic acid (DHA, C22:6 n-3) synthesis in bovine mammary epithelial cells (BMECs). We found that rapamycin decreased the relative abundance of ELOVL1 mRNA, ELOVL1 expression and the level of DHA in a time-dependent manner. These data indicate that ELOVL1 expression and DHA synthesis are regulated by mTORC1 in BMECs.
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