期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 181, 期 -, 页码 639-647出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.06.001
关键词
Isatin; Aryldiazonium salts; Biosensors; Surface functionalization; Heterogeneous Sonogashira cross-coupling
资金
- Labex SYNORG [ANR-11-LABX-0029]
- Region Normandie (CRUNCh)
- Region Normandie (Sesa network)
- ERDF
The grafting of 5-iodoisatin heterocycle on a cyclic olefin copolymer (COC) and a gold surface was performed using a heterogeneous phase Sonogashira reaction consisting of coupling 5-iodoisatin with an arylalkyne previously introduced onto the surfaces. This optimized strategy takes advantage of the well-established methodology to functionalize COC or gold surfaces using aryldiazonium surface chemistry. Herein, we reported the first example of an isatin decorated polymeric or metallic surface. The surfaces were analyzed with a combination of techniques such as IR (Infrared spectroscopy), XPS (X-Ray photoelectron spectroscopy) and SPR (surface plasmon resonance). Docking studies showed that isatin and two derivatives interact with AmiC, a dimeric protein produced by Pseudomonas aeruginosa. Bacterial adhesion on isatin - COC platform was also observed. This general strategy for robust surface functionalization represents an easy approach for patterning surfaces with compounds of biological interest, allowing access to a large panel of original biosensors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据