期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 180, 期 -, 页码 237-244出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2019.04.043
关键词
Photocatalytic antibacterial activity; Wound dressing; Hydrogel; Wound healing
资金
- National Natural Science Foundation of China [21866028, 61704114, 51662036]
- Graduate student scientific research innovation projects in Xinjiang autonomous region [XJGRI2017046]
- Open Foundation of Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan [2016BTRC005]
- Shihezi University [CGZH201603]
A novel antibacterial hydrogel was prepared through the addition of IT to a chitin (CT) and polyvinyl alcohol (PVA) hydrogel, creating a promising material for wound dressings. The addition of nano particles IT endowed the anti-bacterial activity of hydrogel as well as had a positive impact on the mechanical properties of the hydrogels. The structure of the prepared hydrogel dressing was characterized by FTIR, XPS, XRD, SEM and TEM. The composite hydrogel exhibited excellent anti-bacterial activity under the visible light. Cytotoxicity tests (L929 fibroblast cells) showed all samples achieving up to 80% cell viability. Furthermore, compared with conventional dressings, wound healing test revealed that CT/PVA/IT hydrogel could accelerated wound healing in vivo, wound closure rates reached 95.5% after 10 days. This study suggests that the novel hydrogel has considerable potential for applications in wound dressings.
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