期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 181, 期 -, 页码 585-592出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2019.06.013
关键词
Zinc oxide nanocomposite; Layered double hydroxides; In situ hydrothermal treatment; Potent and durable antibacterial activity
资金
- Australian Research Council (ARC) [DP170104643]
- National Natural Science Foundation of China [51578329]
- Program for Innovative Research Team in University [IRT13078]
The search for effective alternatives to traditional antibiotics to avoid antibiotic resistant bacteria is growing worldwide. ZnO nanoparticles are found to effectively inhibit growth and proliferation of bacteria, and ZnO-based layered double hydroxides (ZnO-based LDHs) have been intensively investigated for this purpose. However, the nanocomposites are made in a multi-step preparation process with severe agglomeration and limited bactericidal ability. In this research, ZnO-dotted nanohybrids using Zn3Al-LDHs as precursors (ZnO-dotted LDHs or ZnO/LDHs) were synthesized under facile hydrothermal conditions. An understanding of the transformation of the LDH precursors to the ZnO/LDHs was conducted with TEM/HRTEM/XRD/FTIR. ZnO/LDHs can be transformed from ZnAl-LDHs, with more ZnO nanodots generated upon heating at 150 and 200 degrees C for 2 h (Zn3Al-150, Zn3Al-200). Zn3Al-200 nanohybrids showed potent antibacterial activity towards Escherichia colt (E. coli) and Staphylococcus aureus (S. aureus) at 100-300 mu g/mL for 4 days. Antibacterial activity of Zn3Al-200 may be attributed to the synergistic effects (ROS, leached Zn2+ and physical interaction). This research thus suggests a potential economic approach to prepare ZnO/LDH nanocomposites for avoiding the antibiotic resistant bacteria in environmental engineering or clinic fields.
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