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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Behavioral effects of fatty acid amide hydrolase inhibition on morphine withdrawal symptoms
Siamak Shahidi et al.
BRAIN RESEARCH BULLETIN (2011)
The case for peripheral CB1 receptor blockade in the treatment of visceral obesity and its cardiometabolic complications
George Kunos et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
Luciano De Petrocellis et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Dronabinol for the treatment of cannabis dependence: A randomized, double-blind, placebo-controlled trial
Frances R. Levin et al.
DRUG AND ALCOHOL DEPENDENCE (2011)
Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis
Jose L. Lanciego et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2011)
New medications for drug addiction hiding in glutamatergic neuroplasticity
P. W. Kalivas et al.
MOLECULAR PSYCHIATRY (2011)
Brain cannabinoid CB2 receptors modulate cocaine's actions in mice
Zheng-Xiong Xi et al.
NATURE NEUROSCIENCE (2011)
Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition
Andrea Cippitelli et al.
PLOS ONE (2011)
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Antonia Serrano et al.
PHARMACOLOGY & THERAPEUTICS (2011)
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
Daniel K. Nomura et al.
SCIENCE (2011)
Rimonabant: FromRIO to Ban
Amir H. Sam et al.
JOURNAL OF OBESITY (2011)
Blockade of Endocannabinoid Hydrolytic Enzymes Attenuates Precipitated Opioid Withdrawal Symptoms in Mice
Divya Ramesh et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-α nuclear receptors
Antonio Luchicchi et al.
ADDICTION BIOLOGY (2010)
The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice
Daniele Bolognini et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
CB2: a cannabinoid receptor with an identity crisis
Brady K. Atwood et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents
N. L. Cluny et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Blockade of the Cannabinoid CB1 Receptor and Alcohol Dependence: Preclinical Evidence and Preliminary Clinical Data
Paola Maccioni et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)
CB1 Cannabinoid Receptors and their Associated Proteins
Allyn C. Howlett et al.
CURRENT MEDICINAL CHEMISTRY (2010)
Δ9-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats
Andrew J. Hill et al.
EPILEPSIA (2010)
Cannabinoid and Cannabinoid-Like Receptors in Microglia, Astrocytes, and Astrocytomas
Nephi Stella
GLIA (2010)
Reducing endocannabinoid metabolism with the fatty acid amide hydrolase inhibitor, URB597, fails to modify reinstatement of morphine-induced conditioned floor preference and naloxone-precipitated morphine withdrawal-induced conditioned floor avoidance
Amanda L. McCallum et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2010)
Inhibitors of Endocannabinoid-Metabolizing Enzymes Reduce Precipitated Withdrawal Responses in THC-Dependent Mice
Joel E. Schlosburg et al.
AAPS JOURNAL (2009)
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
Gernot Riedel et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism
Jonathan Z. Long et al.
CHEMISTRY & BIOLOGY (2009)
Molecular Identification of Albumin and Hsp70 as Cytosolic Anandamide-Binding Proteins
Sergio Oddi et al.
CHEMISTRY & BIOLOGY (2009)
Novel endogenous peptide agonists of cannabinoid receptors
Ivone Gomes et al.
FASEB JOURNAL (2009)
Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
Yanhua Ren et al.
JOURNAL OF NEUROSCIENCE (2009)
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Jonathan Z. Long et al.
NATURE CHEMICAL BIOLOGY (2009)
AGONISM OF THE ENDOCANNABINOID SYSTEM MODULATES BINGE-LIKE ALCOHOL INTAKE IN MALE C57BL/6J MICE: INVOLVEMENT OF THE POSTERIOR VENTRAL TEGMENTAL AREA
D. N. Linsenbardt et al.
NEUROSCIENCE (2009)
Endocannabinoid-Mediated Control of Synaptic Transmission
Masanobu Kano et al.
PHYSIOLOGICAL REVIEWS (2009)
FAAH inhibitor, URB-597, promotes extinction and CB1 antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats
Laurie A. Manwell et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2009)
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
Jonathan Z. Long et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Identification of intracellular carriers for the endocannabinoid anandamide
Martin Kaczocha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Inhibition of fatty acid amide hydrolase reduces reinstatement of nicotine seeking but not break point for nicotine self-administration-comparison with CB1 receptor blockade
Benoit Forget et al.
PSYCHOPHARMACOLOGY (2009)
The future of endocannabinoid-oriented clinical research after CB1 antagonists
Bernard Le Foll et al.
PSYCHOPHARMACOLOGY (2009)
The role of CB1 receptors in psychostimulant addiction
Joost Wiskerke et al.
ADDICTION BIOLOGY (2008)
Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates
Zuzana Justinova et al.
BIOLOGICAL PSYCHIATRY (2008)
Effects of Δ9-tetrahydrocannabivarin on [35S] GTPγS binding in mouse brain cerebellum and piriform cortex membranes
I. Dennis et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta(9)-tetrahydrocannabinol, cannabidiol and Delta(9)-tetrahydrocannabivarin
R. G. Pertwee
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor
Richard Z. Chen et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine
Styliani Vlachou et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2008)
Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity:: Effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats
F. J. Pavon et al.
JOURNAL OF NEUROENDOCRINOLOGY (2008)
Endogenous Fatty Acid Ethanolamides Suppress Nicotine-Induced Activation of Mesolimbic Dopamine Neurons through Nuclear Receptors
Miriam Melis et al.
JOURNAL OF NEUROSCIENCE (2008)
Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3′-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats
Maria Scherma et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Neurobiological mechanisms of cannabinoid addiction
L. Fattore et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2008)
Endocannabinoids mediate neuron-astrocyte communication
Marta Navarrete et al.
NEURON (2008)
Intrinsic effects of AM4113, a putative neutral CB1 receptor selective antagonist, on open-field behaviors in rats
T. U. C. Jarbe et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2008)
Beta-caryophyllene is a dietary cannabinoid
Juerg Gertsch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat
Andrea Cippitelli et al.
PSYCHOPHARMACOLOGY (2008)
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats
Kelly S. Sink et al.
NEUROPSYCHOPHARMACOLOGY (2008)
Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
Margaret Haney et al.
PSYCHOPHARMACOLOGY (2008)
Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: Experiments with self-administration and brain-stimulation reward in rats
Zheng-Xiong Xi et al.
NEUROPSYCHOPHARMACOLOGY (2008)
The psychoactive plant cannabinoid, Delta(9)-tetrahydrocannabinol, is antagonized by Delta(8)- and Delta(9)-tetrahydrocannabivarin in mice in vivo
R. G. Pertwee et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences
J. M. McPartland et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
A. Thomas et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
A neutral CB1 receptor antagonist reduces weight gain in rat
Adam P. Chambers et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Cannabinoid CB1 receptor inverse agonists and neutral antagonists:: Effects on food intake, food-reinforced behavior and food aversions
John D. Salamone et al.
PHYSIOLOGY & BEHAVIOR (2007)
Lack of evidence for appetitive effects of Δ9-tetrahydrocannabinol in the intracranial self-stimulation and conditioned place preference procedures in rodents
Styliani Vlachou et al.
BEHAVIOURAL PHARMACOLOGY (2007)
Role of endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase
Yuri A. Blednov et al.
NEUROPSYCHOPHARMACOLOGY (2007)
The anandamide transport inhibitor AM404 reduces ethanol self-administration
Andrea Cippitelli et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration
Stephanie Caille et al.
JOURNAL OF NEUROSCIENCE (2007)
Oral delta-9-tetrahydrocannabinol suppresses cannabis withdrawal symptoms
Alan J. Budney et al.
DRUG AND ALCOHOL DEPENDENCE (2007)
Effects of endocannabinoid neurotransmission modulators on brain stimulation reward
Styliani Vlachou et al.
PSYCHOPHARMACOLOGY (2006)
Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole-LH 21
Francisco Javier Pavon et al.
NEUROPHARMACOLOGY (2006)
Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats
Marcello Solinas et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice
Balapal S. Basavarajappa et al.
NEUROPHARMACOLOGY (2006)
Involvement of the endocannabinoid system in drug addiction
R Maldonado et al.
TRENDS IN NEUROSCIENCES (2006)
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597)
Daniele Piomelli et al.
CNS DRUG REVIEWS (2006)
Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia
F Matyas et al.
NEUROSCIENCE (2006)
The endocannabinoid system as an emerging target of pharmacotherapy
Pal Pacher et al.
PHARMACOLOGICAL REVIEWS (2006)
2-arachidonoylglycerol (2-AG) membrane transport: History and outlook
Anita Hermann et al.
AAPS JOURNAL (2006)
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
G Gobbi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Evidence that the plant cannabinoid Δ9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist
A Thomas et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats
M Solinas et al.
NEUROPSYCHOPHARMACOLOGY (2005)
Allosteric modulation of the cannabinoid CB1 receptor
MR Price et al.
MOLECULAR PHARMACOLOGY (2005)
Mechanism of carbamate inactivation of FAAH: Implications for the design of covalent inhibitors and in vivo functional probes for enzymes
JP Alexander et al.
CHEMISTRY & BIOLOGY (2005)
CB2 receptor ligands
JW Huffman
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2005)
Endocannabinoid release from midbrain dopamine neurons: A potential substrate for cannabinoid receptor antagonist treatment of addiction
CR Lupica et al.
NEUROPHARMACOLOGY (2005)
Endocannabinoid signaling system and brain reward: Emphasis on dopamine
EL Gardner
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2005)
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients:: 1-year experience from the RIO-Europe study
LF Van Gaal et al.
LANCET (2005)
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
KJ Valenzano et al.
NEUROPHARMACOLOGY (2005)
Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence
B Le Foll et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Endocannabinoid Metabolic Pathways and Enzymes
Alessia Ligresti et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors
M Melis et al.
JOURNAL OF NEUROSCIENCE (2004)
Effect of low doses of Δ9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats
LA Parker et al.
PSYCHOPHARMACOLOGY (2004)
Marijuana and cannabinoid regulation of brain reward circuits
CR Lupica et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis
DC D'Souza et al.
NEUROPSYCHOPHARMACOLOGY (2004)
Δ9-Tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats
D Braida et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Exposure to Δ-9-tetrahydrocannabinol (THC) increases subsequent heroin taking but not heroin's reinforcing efficacy:: A self-administration study in rats
M Solinas et al.
NEUROPSYCHOPHARMACOLOGY (2004)
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
D Fegley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Marijuana withdrawal in humans: Effects of oral THC or divalproex
M Haney et al.
NEUROPSYCHOPHARMACOLOGY (2004)
RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
TP Dinh et al.
MOLECULAR PHARMACOLOGY (2004)
Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif
N Jagerovic et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain:: Pain inhibition by receptors not present in the CNS
MM Ibrahim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Self-administration of Δ9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys
Z Justinova et al.
PSYCHOPHARMACOLOGY (2003)
Role of endogenous cannabinoids in synaptic signaling
TF Freund et al.
PHYSIOLOGICAL REVIEWS (2003)
The molecular logic of endocannabinoid signalling
D Piomelli
NATURE REVIEWS NEUROSCIENCE (2003)
Modulation of anxiety through blockade of anandamide hydrolysis
S Kathuria et al.
NATURE MEDICINE (2003)
Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids
B Szabo et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2002)
Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain
S Mato et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2002)
Resorcinol derivatives:: A novel template for the development of cannabinoid CB1/CB2 and CB2-selective agonists
JL Wiley et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats
G Colombo et al.
PSYCHOPHARMACOLOGY (2002)
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
T Bisogno et al.
BRITISH JOURNAL OF PHARMACOLOGY (2001)
Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats
L Fattore et al.
PSYCHOPHARMACOLOGY (2001)
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys
G Tanda et al.
NATURE NEUROSCIENCE (2000)
2-arachidonoylglycerol and the cannabinoid receptors
T Sugiura et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2000)
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor
JP Mothet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
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