期刊
CLINICS IN GERIATRIC MEDICINE
卷 36, 期 1, 页码 1-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cger.2019.08.002
关键词
Parkinson disease; Pathology; Epidemiology; Genetics; Pathophysiology; Mitochondrial; Synuclein; Neuroprotection
资金
- NIA NIH HHS [R01 AG059417] Funding Source: Medline
- NIDCD NIH HHS [R01 DC016519] Funding Source: Medline
- NINDS NIH HHS [R01 NS086352, R21 NS094840] Funding Source: Medline
Parkinson disease is a complex, age-related, neurodegenerative disease associated with dopamine deficiency and both motor and nonmotor deficits. Many environmental and genetic factors influence Parkinson disease risk, with different factors predominating in different patients. These factors converge on specific pathways, including mitochondrial dysfunction, oxidative stress, protein aggregation, impaired autophagy, and neuroinflammation. Ultimately, treatment of Parkinson disease may focus on targeted therapies for pathophysiologically defined subtypes of Parkinson disease patients.
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