期刊
CLINICAL INFECTIOUS DISEASES
卷 71, 期 4, 页码 1055-1062出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciz916
关键词
Kaposi's sarcoma herpesvirus DNA; risk factors; Uganda
资金
- African Partnership for Chronic Disease Research, University of Cambridge, United Kingdom
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- Intramural Research Program of the National Institutes of Health, National Cancer Institute
- Makerere University/UVRI Centre of Excellence for Infection and Immunity Research and Training through the The Developing Excellence in Leadership, Training And Science Africa Initiative [107743]
- African Academy of Sciences
- Alliance for Accelerating Excellence in Science in Africa by the New Partnership for Africa's Development Planning and Coordinating Agency
- Wellcome Trust [107743]
- UK government
- UK MRC
- UK Department for International Development (DFID) under the MRC/DFID Concordat agreement
- European Union
- MRC [MC_UU_00027/2] Funding Source: UKRI
Background: Detectable Kaposi's sarcoma-associated herpesvirus (KSHV) DNA in blood and increased antibody titres may indicate KSHV reactivation, while the transmission of KSHV occurs via viral shedding in saliva. Methods: We investigated the risk factors for KSHV DNA detection by real-time polymerase chain reaction in blood and by viral shedding in saliva, in 878 people aged 3 to 89 years of both sexes in a rural Ugandan population cohort. Helminths were detected using microscopy and the presence of malaria parasitaemia was identified using rapid diagnostic tests. Regression modelling was used for a statistical analysis. Results: The KSHV viral load in blood did not correlate with the viral load in saliva, suggesting separate immunological controls within each compartment. The proportions of individuals with a detectable virus in blood were 23% among children aged 3-5 years and 22% among those 6-12 years, thereafter reducing with increasing age. The proportions of individuals with a detectable virus in saliva increased from 30% in children aged 3-5 years to 45% in those aged 6-12 years, and decreased subsequently with increasing age. Overall, 29% of males shed in saliva, compared to 19% of females (P = .008). Conclusions: Together, these data suggest that young males may be responsible for much of the onward transmission of KSHV. Individuals with a current malaria infection had higher levels of viral DNA in their blood (P = .031), compared to uninfected individuals. This suggests that malaria may lead to KSHV reactivation, thereby increasing the transmission and pathogenicity of the virus.
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