期刊
CLINICAL CHEMISTRY
卷 65, 期 10, 页码 1317-1326出版社
OXFORD UNIV PRESS INC
DOI: 10.1373/clinchem.2019.306431
关键词
-
资金
- Ortho Clinical Diagnostics
- Royal Children's Hospital Foundation
BACKGROUND: Age-specific reference intervals (RIs) have been developed for biochemistry analytes in children. However, the ability to interpret results from multiple laboratories for 1 individual is limited. This study reports a head-to-head comparison of reference values and age-specific RIs for 30 biochemistry analytes for children across 5 analyzer types. METHODS: Blood was collected from healthy newborns and children 30 days to <18 years of age. Serum aliquots from the same individual were analyzed on 5 analyzer types. Differences in the mean reference values of the analyzes by the analyzer types were investigated using mixed-effect regression analysis and by comparing maximum variation between analyzers with analyte-specific allowable total error reported in the Westgard QC database. Quantile regression was used to estimate age-specific Ms using power variables in age selected by fractional polynomial regression for the mean, with modification by sex when appropriate. RESULTS: The variations of age-specific mean reference values between analyzer types were within allowable total error (Westgard QC) for most analytes, and common age-specific reference limits were reported as functions of age and/or sex. Analyzer-specific reference limits for all analyzes on 5 analyzer types are also reported as functions of age and/or sex. CONCLUSIONS: This study provides quantitative and qualitative measures of the extent to which results for individual children can or cannot be compared across analyzer types, and the feasibility of RI harmonization. The reported equations enable incorporation of age-specific Ms into laboratory information systems for improving evidence-based clinical decisions in children. (C) 2019 American Association for Clinical Chemistry
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据