期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 14, 期 19, 页码 3335-3343出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201900982
关键词
guanidine; hypervalent iodine; one-pot synthesis; reactions in water; surfactants
资金
- Thailand Research Fund [RSA6080018, RTA6180007]
- National Nanotechnology Center, NSTDA, Ministry of Science and Technology, Thailand, through its program of Research Network NANOTEC (RNN)
- Center of Excellence on Petrochemical and Materials Technology (PETROMAT), Thailand
- Grant for International Research Integration: Chula Research Scholar
In this work, we developed a one-pot synthesis of guanidine directly from isothiocyanate using DIB (diacetoxyiodobenzene) as a desulfurizing agent under micellar conditions in water. Our optimization study revealed that the use of 1 % TPGS-750-M as a surfactant with NaOH as an additive base at room temperature can convert a variety of isothiocyanates and amines into corresponding guanidines in excellent yields (69-95 %). This synthetic process in water can be applied to prepare guanidine at gram-scale quantity. Our aqueous micellar medium also demonstrated high reusability as the reaction can be performed for several cycles without losing its efficiency. The reaction is metal-free, utilizes water as solvent and practical (room temperature and open flask).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据