期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 65, 页码 14740-14757出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201903127
关键词
antitumor agents; bioorthogonal reactions; drug delivery; photocages; prodrugs
资金
- Ministero dell'Universite della Ricerca [20157WW5EH]
The covalent conjugation of potent cytotoxic agents to either macromolecular carriers or small molecules represents a well-known approach to increase the therapeutic index of these drugs, thus improving treatment efficacy and minimizing side effects. In general, cytotoxic activity is displayed only upon cleavage of a specific chemical bond (linker) that connects the drug to the carrier. The perfect balance between the linker stability and its selective cleavage represents the key for success in these therapeutic approaches and the chemical toolbox to reach this goal is continuously expanding. In this Review article, we highlight recent advances on the different modalities to promote the selective release of cytotoxic agents, either by exploiting specific hallmarks of the tumor microenvironment (e.g. pH, enzyme expression) or by the application of external triggers (e.g. light and bioorthogonal reactions).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据