期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 25, 期 59, 页码 13472-13478出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201903278
关键词
antibiotics; cationic chalcogenoviologens; membrane intercalating agents; photodynamic antimicrobial therapy; skin regeneration
资金
- Natural Science Foundation of China [21704081, 21875180, 81601606]
- Fundamental Research Funds for the Central Universities [1191329805, 2016qngz02]
- Natural Science Foundation of Shaanxi province [2018JM2026, 2017JM5023]
- Cyrus Chung Ying Tang Foundation
- National 1000-Plan program
A series of water-soluble cationic chalcogenoviologen-based photosensitizers for photodynamic antimicrobial therapy (PDAT) is reported. The Se-containing derivatives (SeMV2+) 5 b and 6 b showed good antimicrobial activities due to the presence of chalcogen atoms and a cationic scaffold. The former efficiently enhanced the generation of reactive oxygen species (ROS), and the latter facilitated the ROS delivery to bacteria, resulting in their death. Interestingly, alkyl-modified photosensitizers showed higher antimicrobial activities than commonly reported photosensitizers with quaternary ammonium (QA) groups. In particular, the SeMV2+ (6 b) with excellent antibacterial activities efficiently promoted the healing of infected wounds in mice. Simple yet novel, nontoxic and biocompatible chalcogenoviologens provided a promising strategy to develop new efficient photosensitizers for photodynamic antimicrobial therapy and skin regeneration.
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