期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 6, 页码 1166-1195出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201903128
关键词
antitumor agents; bioactivity; bryostatins; drug discovery; total synthesis
资金
- NSFC [21702157, 21602174, 81673564]
- Fundamental Research Funds for the Central Universities [Z201806045]
- Nature Science Foundation of Shaanxi Province [2019JZ-01]
Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014-present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1, the most-studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据