期刊
CHEMISTRY & BIODIVERSITY
卷 16, 期 9, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201900326
关键词
microorganisms; fungus; hydrothermal; secondary metabolites; polyketides; cytotoxicity
资金
- Scientific Research Foundation of Third Institute of Oceanography [2017035]
- COMRA Program [DY135-B2-08]
- National Natural Science Foundation of China [41606185]
Chromatographic separation of the AcOEt extract of the fermented cultures of the deep-sea-derived fungus Graphostroma sp. resulted in the isolation of 11 new chained polyketides, namely graphostromols A-K (1-11). The structures of the new compounds were established by the extensive analyses of their NMR and HR-ESI-MS data. The absolute configuration at C-11 in 1 was determined on the basis of the modified Mosher's method. Compounds 1-5, bearing a 2,2,10,10-tetramethyldodecane skeleton, were discovered for the first time from nature. All isolates were evaluated for their cytotoxicities against five different cancer cell lines (HeLa, Eca-109, Biu-87, Bel-7402, and PANC-1). However, none showed positive effects.
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