期刊
CHEMICAL ENGINEERING JOURNAL
卷 382, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.123019
关键词
Hybrid hydrogel; Osteoimmunomodulation; Antibacterial; Combination therapy; Bone regeneration
资金
- National Natural Science Foundation of China [81371793, 5150030109]
- Guangdong Innovative Research Team program [2009010058]
- Science and Technology Planning Project of Shenzhen [JCYJ20180307163534533]
After a biomaterial is implanted in a bone defect area, the immune response and bacterial infection affect the success of bone regeneration. In this study, we describe the development of a promising therapeutic approach to accelerate bone regeneration via combining osteoimmunomodulatory and antibacterial activities. Herein, we fabricated a nanosilver/halloysite nanotubes/gelatin methacrylate (nAg/HNTs/GelMA) hybrid hydrogel and evaluated its osteoimmunomodulatory and antibacterial properties in vitro and in vivo. The nAg/HNTs/GelMA hybrid hydrogel had good biocompatibility with human periodontal ligament stem cells (hPDLSCs) and macrophages. Moreover, the nAg/HNTs/GelMA hybrid hydrogel modulated inflammatory cytokines secreted by macrophages and enhanced the osteogenic differentiation of hPDLSCs in an inflammatory environment. In addition, nAg/HNTs/GelMA hybrid hydrogel inhibited the growth of Gram-positive and Gram-negative bacteria in vitro and in vivo. Compared with HNTs/GelMA hydrogel, the nAg/HNTs/GelMA hybrid hydrogel better modulated the osteoimmune microenvironment and eliminated bacterial infection. Thus, this hybrid hydrogel combining osteoimmunomodulatory with antibacterial activities is a promising biomaterial for bone regeneration in defect areas.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据