期刊
CELL METABOLISM
卷 30, 期 3, 页码 414-433出版社
CELL PRESS
DOI: 10.1016/j.cmet.2019.08.011
关键词
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资金
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at the Sun Yat-Sen University
- National Natural Science Foundation of China [81670855]
- Guangdong Province Leading Expert Program grant
- Key Program of Guangzhou Scientific Research Plan [3030901006074]
- long-term structural Methusalem by Flemish Government
- Research Foundation Flanders (FWO-Vlaanderen)
- Foundation against Cancer [2016-078]
- Kom op Tegen Kanker (Stand up to Cancer, Flemish Cancer Society)
- ERC Advanced Research Grant [EU-ERC743074]
In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the orders of growth factors if these cells would accordingly adapt their metabolism. Ten years later, it has become clear that ECs, often differently from other cell types, rely on distinct metabolic pathways to survive and form new blood vessels; that manipulation of EC metabolic pathways alone (even without changing angiogenic signaling) suffices to alter vessel sprouting; and that perturbations of these metabolic pathways can underlie excess formation of new blood vessels (angiogenesis) in cancer and ocular diseases. Initial proof of evidence has been provided that targeting (normalizing) these metabolic perturbations in diseases ECs and delivery of metabolites deserve increasing attention as novel therapeutic approaches for inhibiting or stimulating vessel growth in multiple disorders.
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