期刊
CELL METABOLISM
卷 30, 期 2, 页码 238-250出版社
CELL PRESS
DOI: 10.1016/j.cmet.2019.06.019
关键词
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资金
- Communication Disorders of the National Institutes of Health [R21DC013172, 1R56DC016415-01]
- Swedish Medical Research Council [K2014-99X-22478-01-3]
- Knut and Alice Wallenberg Foundation [KAW2008]
- Karolinska Institutet
- Tysta Skolan
- Horselforskningsfonden
- Magnus Bergvalls
- EU (H2020-MSCA-ITN, ESIT) [722046]
- Office of the Assistant Secretary of Defense for Health Affairs, through the Neurosensory and Rehabilitation program [W81XWH-16-1-0032]
- German Research Foundation (DFG) [FO207/15-1]
- EU (H2020-MSCA-ITN-2017, CINCHRON) [765937]
- NIH [R35 GM127122]
- UK Medical Research Council, U.K. [MC_U105170643]
- Swiss National Science Foundation [SNF 310030_184667/1]
- Velux Foundation [995]
- CRUK [C53561/A 19933]
- MRC [MR/M013170]
- Philips Respironics (USA)
- McGrath Family
- Ramsay-Generale-de-Sante (Fr)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01DK090625, R01DK100814, R01DK11301, R01DK050203]
- National Institute on Aging grant [P01AG011412]
- Chicago Biomedical Consortium [S-007]
- University of Chicago Diabetes Research and Training Center [P60DK020595]
- Institute for Molecular Bioscience, The University of Queensland
- Velux Foundation
- Human Frontiers Science Program
- National Institutes of Health [GM054339]
- MRC [MC_U105170643] Funding Source: UKRI
The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics. Thus, it is now time that circadian factors become an integral part of translational research.
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