期刊
CELL HOST & MICROBE
卷 26, 期 2, 页码 283-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2019.07.008
关键词
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资金
- National Institutes of Health NIEHS [T32 DK110919, R00ES23504, R21ES205052]
- National Science Foundation [1636870]
- National Institute of Allergy and Infectious Diseases [R01AI127250]
- American Diabetes Association (ADA) Pathway to Stop Diabetes Initiator Award [1-17-INI-13]
- Smith Family Foundation Award for Excellence in Biomedical Research
- Direct For Computer & Info Scie & Enginr
- Office of Advanced Cyberinfrastructure (OAC) [1636870] Funding Source: National Science Foundation
Despite substantial interest in the species diversity of the human microbiome and its role in disease, the scale of its genetic diversity, which is fundamental to deciphering human-microbe interactions, has not been quantified. Here, we conducted a cross-study meta-analysis of metagenomes from two human body niches, the mouth and gut, covering 3,655 samples from 13 studies. We found staggering genetic heterogeneity in the dataset, identifying a total of 45,666,334 non-redundant genes (23,961,508 oral and 22,254,436 gut) at the 95% identity level. Fifty percent of all genes were singletons, or unique to a single metagenomic sample. Singletons were enriched for different functions (compared with non-singletons) and arose from sub-population-specific microbial strains. Overall, these results provide potential bases for the unexplained heterogeneity observed in microbiome-derived human phenotypes. One the basis of these data, we built a resource, which can be accessed at https://microbial-genes.bio.
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