期刊
CELL
卷 178, 期 6, 页码 1509-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2019.08.009
关键词
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资金
- Singapore Immunology Network (SIgN)
- Singapore National Research Foundation Senior Investigatorship (NRFI) [NRF2016NRF-NRFI001-02]
- BMRC [IAF 311006]
- BMRC transition funds [H16/99/b0/011]
- National Natural Science Foundation of China (NSFC) [31470845, 81430033, 31670896]
- Shanghai Science and Technology Commission (SSTC) [13JC1404700]
- NSFC [31870871]
- SSTC [17PJ1408300, 17ZR1425000]
Most tissue-resident macrophage (RTM) populations are seeded by waves of embryonic hematopoiesis and are self-maintained independently of a bone marrow contribution during adulthood. A proportion of RTMs, however, is constantly replaced by blood monocytes, and their functions compared to embryonic RTMs remain unclear. The kinetics and extent of the contribution of circulating monocytes to RTM replacement during homeostasis, inflammation, and disease are highly debated. Here, we identified Ms4a3 as a specific gene expressed by granulocyte-monocyte progenitors (GMPs) and subsequently generated Ms4a3(TdT) reporter, Ms4a3(Cre), and Ms4a3(CreERT2) fate-mapping models. These models traced efficiently monocytes and granulocytes, but no lymphocytes or tissue dendritic cells. Using these models, we precisely quantified the contribution of monocytes to the RTM pool during homeostasis and inflammation. The unambiguous idenification of monocyte-derived cells will permit future studies of their function under any condition.
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