期刊
CELL
卷 178, 期 5, 页码 1057-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2019.07.018
关键词
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资金
- Arthur J. Schmitt Leadership Fellowship in Science and Engineering
- Eck Institute for Global Health Graduate Fellowship
- Branco Weiss Fellowship-Society in Science
- National Institute of Child Health and Human Development [T32HD040128]
- Centers for Disease Control and Prevention [U50CK00189]
- Public Health Agency of Canada
- Interne Fondsen KU Leuven/Internal Funds KU Leuven [C14/18/094]
- RAPID award from the National Science Foundation [DEB 1641130]
- Defense Advanced Research Projects Agency [D16AP0014]
- NIH NIAID [R01AI099210]
- NIH NCATS CTSA [UL1TR002550]
- NIAID [U19AI135995, HHSN272201400048C, R21AI137690]
- Ray Thomas Foundation
- International Society of Travel Medicine
- NWO Rubicon [019.181EN. 004]
The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identify transmission not captured by reporting. We uncovered an unreported outbreak in Cuba during 2017, a year after peak transmission in neigh-boring islands. By sequencing Zika virus, we show that the establishment of the virus was delayed by a year and that the ensuing outbreak was sparked by long-lived lineages of Zika virus from other Caribbean islands. Our data suggest that, although mosquito control in Cuba may initially have been effective at mitigating Zika virus transmission, such measures need to be maintained to be effective. Our study highlights how Zika virus may still be ''silently'' spreading and provides a framework for understanding outbreak dynamics.
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