期刊
CARBOHYDRATE POLYMERS
卷 217, 期 -, 页码 207-216出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.04.046
关键词
Antifungal activity; Bacterial nanocellulose; Candida albicans; Cutaneous treatment; In-situpolymerization; Poly([2-(methacryloyloxy) ethyl] trimethylammonium chloride)
资金
- FCT/MEC [UID/CTM/50011/2019, UID/AMB/50017/2019]
- FCT - Fundacao para a Ciencia e a Tecnologia, I.P.
- FCT under Stimulus of Scientific Employment 2017 [CEECIND/00464/2017]
The design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2-(methacryloyloxy) ethyl] trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional network enabled the in-situ polymerization of the non-toxic and bioactive quaternary-ammonium monomer, which originated transparent nanocomposites containing 10 and 40 wt.% of cross-linked PMETAC. Furthermore, the nanocomposites exhibit UV-A and UV-B blocking properties, high water-uptake capacity, thermal stability up to 200 degrees C, good viscoelastic (storage modulus > 1.7 GPa) and mechanical (Young's modulus >= 2.4 GPa) properties and are non-cytotoxic to human keratinocytes (HaCaT cells). The fungal inactivation reached a 4.4 +/- 0.14-log CFU reduction for the nanocomposite containing only 10 wt.% of cross-linked PMETAC. Hence, these bioactive and non-cytotoxic materials can constitute potentially effective systems for the treatment of C. albicans infections.
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