期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 167, 期 4, 页码 536-540出版社
SPRINGER
DOI: 10.1007/s10517-019-04568-z
关键词
olfactory ensheathing cells; olfactory mucosa; cell therapy; cysts of spinal cord; spinal cord injury
资金
- Russian Science Foundation [17-15-01133]
- Russian Science Foundation [17-15-01133] Funding Source: Russian Science Foundation
Olfactory ensheathing cells showed significant effects on the regeneration of the spinal cord in experimental models and in clinical trials. However, the use of these cells in the therapy of posttraumatic cysts of the spinal cord has not been studied. Cultures of human and rat olfactory mucosa were obtained according to the protocols developed by us. Passage 3-4 cultures are most enriched with olfactory ensheathing cells and are preferable for transplantation. We performed transplantation of 750,000 olfactory ensheathing cells into the region of modeled cysts. The therapeutic effect of human cells was more pronounced. The positive dynamics of recovery of motor activity in the hind limbs of rats can reflect regenerative processes in the spinal cord after transplantation of olfactory ensheathing cells into the region of posttraumatic cysts.
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